Via: BMO Capital Markets
OncoMed (OMED) presented updated results from two phase 1b trials of
demcizumab (anti-DLL4) at the ESMO 2014 Congress over the weekend. Both
studies demonstrated encouraging tumor response rates. In the pancreatic cancer
study, demcizumab + gemcitabine + ABRAXANE demonstrated a 41% partial
response (PR) rate and a 45% stable disease (SD) rate, resulting in an overall
clinical benefit rate of 86%. In the non-squamous NSCLC study, demcizumab +
ALIMTA + carboplatin demonstrated 3% CR, 45% PR, and 39% SD, resulting
in an overall clinical benefit rate of 88%. Demcizumab was described as
generally well tolerated in both studies. The truncated dosing schedule for
demcizumab appeared to prevent the onset of late cardiopulmonary toxicity, as
none of the 64 patients in the two studies who received the truncated dosing
experienced any moderate-to-severe cardiopulmonary toxicities. Phase 2 studies
in these two cancer indications are expected to commence by the end of 2014.
Read More: http://research-ca.bmocapitalmarkets.com/documents/c70fa216-f89c-471b-b35e-2b0b16304167.pdf
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