REDWOOD CITY, Calif., Feb. 18, 2014 (GLOBE NEWSWIRE) -- OncoMed Pharmaceuticals, Inc. (OMED), a clinical-stage company developing novel therapeutics that target cancer stem cells (CSCs), or tumor-initiating cells, today announced that it has started a multi-center Phase 1b clinical trial of OMP-54F28 (Fzd8-Fc) with sorafenib (Nexavar(R)) in hepatocellular cancer (HCC). OMP-54F28 is a first-in-class Wnt-pathway-targeting decoy receptor and is part of OncoMed's collaboration with Bayer Pharma AG (Bayer). This is the second of three Phase 1b trials for OMP-54F28 to begin patient enrollment; earlier this year OncoMed initiated a Phase 1b of OMP-54F28 with nab-paclitaxel (Abraxane(R)) and gemcitabine in pancreatic cancer.
The Phase 1b clinical trial is a dose-escalation study of OMP-54F28 in combination with sorafenib in patients with first-line locally advanced or metastatic HCC. Primary objectives of the trial are to evaluate safety of this combination regimen and determine a recommended Phase 2 dose for OMP-54F28 in combination with sorafenib. Key secondary and exploratory objectives include evaluation of the pharmacokinetics (PK) and pharmacodynamics (PD) of OMP-54F28, as well as the efficacy of this combination. Tumor tissue from patients will be used to explore predictive biomarker hypotheses related to the efficacy of OMP-54F28.
Safi Shahda, M.D., Assistant Professor of Clinical Medicine at Indiana University in Indianapolis, IN, is the principal investigator who treated the first patient enrolled in this study. Dr. Shahda commented, "Hepatocellular cancer is a devastating form of liver cancer that is a significant cause of cancer-related death worldwide. Patients with more advanced disease have very few treatment options. OMP-54F28 holds the potential to make a real difference for these patients as it was designed to attack so-called cancer stem cells that can generate new cancer cells and are particularly resistant to currently available cancer drugs."
Read more: http://finance.yahoo.com/news/oncomed-pharmaceuticals-initiates-second-phase-133000941.html
OncoMed Pharmaceuticals Initiates Second Phase 1b Clinical Trial for OMP-54F28 (Fzd8-Fc) With Sorafenib (Nexavar(R)) in Hepatocellular Cancer
Via Yahoo! Finance:
Blue Cross And Blue Shield Of Louisiana Joins With Omada Health To Offer Cutting-Edge Diabetes Prevention Program
BATON ROUGE – Many of us know a family member, friend or other loved one who is living with diabetes. There are 27 million Americans who have diabetes, and Louisiana has the second-highest diabetes mortality rate in the nation. Blue Cross and Blue Shield of Louisiana is taking a leading role in addressing this condition, becoming the first health insurance company and employer in Louisiana to implement an online diabetes prevention program, called Prevent, in partnership with Omada Health.
REDWOOD CITY, Calif., Feb. 3, 2014 (GLOBE NEWSWIRE) -- OncoMed Pharmaceuticals, Inc. (Nasdaq:OMED), a clinical-stage company developing novel therapeutics that target cancer stem cells (CSCs), or tumor-initiating cells, today announced the issuance of its fourth broad U.S. patent relating to antibodies that target the RSPO-LGR cancer stem cell pathway. The new patent, U.S. Patent No. 8,628,774, covers certain methods of treating cancer with antibodies that bind human leucine-rich repeat-containing G protein-coupled receptor (LGR) proteins and either disrupt the binding of such proteins to their ligands, the R-spondin (RSPO) proteins, or disrupt RSPO activation of LGR signaling. RSPO-LGR pathway patents previously granted to OncoMed include U.S. Patent Nos. 8,158,757, 8,158,758 and 8,540,989.
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TetraLogic Announces Licensing and Research Collaboration With Walter and Eliza Hall Institute of Medical Research
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Via PR Newswire:
SUNNYVALE, Ca., Jan. 13, 2014 /PRNewswire/ -- Silk Road Medical, Inc., a developer of advanced devices for the treatment of Carotid Artery disease, announced today the appointment of Sumaira Macdonald, MD, PhD to the position of Chief Medical Officer effective immediately. In this new role, Dr. Macdonald will direct the company's scientific and technical agenda and lead research in ground breaking endovascular interventions for the prevention and treatment of stroke.
Santa Clara, CA, January 13th, 2014 - ProteinSimple today launched Sally Sue and Peggy Sue, the next generation of high throughput Simple Western instruments. These instruments drive the sensitivity of the current high throughput Simple Western systems to performance levels well beyond any traditional Western.
OncoMed Pharmaceuticals Initiates First Phase 1b Clinical Trial of OMP-54F28 (Fzd8-Fc) With Nab-Paclitaxel (Abraxane(R)) and Gemcitabine in Pancreatic Cancer
REDWOOD CITY, Calif., Jan. 13, 2014 (GLOBE NEWSWIRE) -- OncoMed Pharmaceuticals, Inc. (Nasdaq:OMED), a clinical-stage company developing novel therapeutics that target cancer stem cells (CSCs), or tumor-initiating cells, today announced that it has started a multi-center Phase 1b clinical trial of its first-in-class Wnt-pathway-targeting decoy receptor OMP-54F28 (Fzd8-Fc) with nab-paclitaxel (Abraxane®) and gemcitabine in pancreatic cancer. This trial is the first of three Phase 1b trials for OMP-54F28 expected to begin patient enrollment in the next few months as part of OncoMed's collaboration with Bayer Pharma AG. This study follows on the recent initiation of OncoMed's Phase 1b program for the Wnt-pathway-targeting antibody vantictumab (OMP-18R5, Anti-Fzd7).
SANTA CLARA, Calif., Jan. 8, 2014 , PRNewswire -- ProteinSimple today introduced Wes, another revolutionary re-invention of the Western blot. Wes is the bold evolution of the popular Simple Western family of instruments, delivering simplicity and performance like no product before it. With just 30 minutes of sample prep, Wes will analyze up to 25 samples in under 3 hours and he will do it all for less than the price of a high-end Western imager. Wes also introduces an innovative suite of consumables that streamline assay workflow and delivers sensitivity that is better than any traditional Western.
Soft Tissue Regeneration, Inc. Announces Financing and Appoints New Members to Board of Directors